王琪琳;桑青;曲爱琴;

• 1:聊城大学生命科学学院
• 2:山东大学生命科学学院

摘要(Abstract)：

通过调查前人对凝集素的研究成果,报道了近年来多糖凝集素的研究现状,综述了凝集素与免疫细胞化学技术方法有关的一些特性及其应用和功能。

关键词(KeyWords)： 多糖;凝集素;特性;免疫功能

Abstract:

Keywords:

基金项目(Foundation): 受山东省科技攻关项目(5LB401);; 聊城大学科研基金资助课题(X071034)资助

作者(Author): 王琪琳;桑青;曲爱琴;

Email:

DOI: 10.13989/j.cnki.0517-6611.2009.05.138

参考文献(References)：

• [1]AJITVARKI,RICHARD CUMMINGS,JEFFREY ESKO,et al.Essentials of gly-cobiology[M].New York:Cold Spring Harbor Laboratory Press,1999.
• [2]PRATIMA N M,VICTOR H,YUICHIRO H,et al.Inhibition of human cancercell growth and metastasis in nude mice by oral intake of modified citruspectin[J].Journal of the National Cancer Institute,2002,94(24):1854-1862.
• [3]NANGIA-MAKKER P,BACCARINI S,RAZ A.Carbohydrate-recognition and an-giogenesis[J].Cancer Metastasis Rev,2000,19:51-57.
• [4]SHARONN,LIS H.History of lectins:From hemagglutinins to biological recogni-tion molecules[J].Glycobiology,2004,14:53-62.
• [5]TIAN B,LI Y,JI X N,et al.Basement membrane proteins play an active role inthe invasive process of human hepato cellular carcinoma cells with high metasta-sis potential[J].Cancer Res Clin Oncol,2005,131(2):80-86.
• [6]NGUYEN T H.Mechanisms of metastasis[J].Clin Demalol,2004,22(3):209-216.
• [7]HSU C C,LIN T W,CHANG W W,et al.Soy asaponin imodified invasive be-havior of cancer by changing cell surface sialic acids[J].Gynecol Oncol,2005,96(2):415-422.
• [8]TAKANO Y,TERANISHI Y,TERASHIMAS S,et al.Lymph node metastasis re-lated carbohydrate epitopes of gastric cancer with submucosal invasion[J].SurgToday,2000,30(12):1073-1082.
• [9]NANGIA-MAKKER P,BACCARINI S,RAZ A.Carbohydraterecognition and an-giogenesis[J].Cancer Metastasis,Rev,2000,19(1/2):51-57.
• [10]OKADA K,SHIMURAT,SUEHIROT,et al.Reduced galectin-expression is anindicator of unfavorable prognosis in gastric cancer[J].Anticancer Res,2006,26(2):1369-1376.
• [11]KE J J,SHAO Q S,LING Z Q.Expression of E-selectin,integrin beta and im-munoglobulin super family member in human gastric carcinoma cells and its clin-icopat hologic significance[J].World J Gast Roenterol,2006,12(22):3609-3611.
• [12]ZHAO Y,LI J,WANG J,et al.Role of cell surface oligosaccharides of mousemammary tumor cell lines in cancer metastasis[J].Indian J Biochem Biophys,2007,44(3):145-151.
• [13]KAWAGUCHI T,TAKAZAWA H,IMAI S,et al.Expression of vicia villosa ag-glutinin(VVA)-binding glycoprotein in primary breast cancer cells in relationto lymphatic metastasis:is a typical MUC1 bearing tn antigen a receptor ofVVA?[J].Breast Cancer Res Treat,2006,98(1):31-43.
• [14]VALENTINER U,HALL D M,BROOKS S A,et al.HPA binding and metasta-sis formation of human breast cancer cell linest ransplanted into severe com-bined immunodeficient(scid)mice[J].Cancer Lett,2005,219(2):233-242.
• [15]SZOKET,KAYSER K,BAUMHAKEL J D,et al.Prognostic significance of en-dogenous adhesion/growth-regulatory lectins in lung cancer[J].Oncology,2005,69(2):167-174.
• [16]DAI Z,LIUY K,CUI J F,et al.Identification and analysis of altered alpha1.6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis[J].Proteomics,2006,6(21):5857-5867.
• [17]CARR B I,KANKE F,WISE M,et al.Clinical evaluation of lens culinaris ag-glutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in his-tologically proven hepatocellular carcinoma in the United States[J].Dig DisScis,2007,52(3):776-782.
• [18]THIES A,BERLINA,BRUNNER G,et al.Glycoconjugate profiling of primarymelanoma and its sentinel node and distant metastases:Implications for diagno-sis and pathophysiology of metastases[J].Cancer Lett,2007,248(1):68-80.
• [19]彭丹红,任慕兰.外阴阴道假丝酵母菌病患者阴道局部甘露糖结合凝集素mRNA水平的测定[J].东南大学学报:医学版,2008,27(2):109-112.