牛蒡子醇提物抑制小鼠宫颈癌U14生长的研究Study on Effect of the Extract from Fructus arctii on the Uterine Cervical Carcinoma(U_(14)) Growth of Mice Harboring Tumor
耿果霞;龙玲;李青旺;王建华;
摘要(Abstract)：
通过建立小鼠宫颈癌U14实体瘤与腹水瘤2种动物模型,观察牛蒡子醇提物对实体瘤抑瘤率和腹水瘤生命延长率的影响。结果发现,以阴性对照组为基础,牛蒡子醇提物3个剂量组及环磷酰胺(CTX)阳性对照组实体瘤各组抑瘤率分别为31.7%、49.7%、57.4%和83.6%(P<0.01);腹水瘤各组生命延长率分别为39.8%、46.6%、62.5%和91.6%(P<0.01)。表明牛蒡子醇提物对小鼠宫颈癌U14的生长有一定的抑制作用。
关键词(KeyWords)： 牛蒡子;U14;实体瘤;腹水瘤
基金项目(Foundation):
作者(Author): 耿果霞;龙玲;李青旺;王建华;
Email:
DOI: 10.13989/j.cnki.0517-6611.2006.21.059
参考文献(References)：
- [1]王劲,沙明,杨洪武,等.HPLC法对不同地区商品牛蒡子中牛蒡苷元的定量分析[J].中草药,2003,34(5):467-468.
- [2]张涛.牛蒡子不同炮制品中牛蒡苷含量的HPLC测定[J].中草药,35(4):406-407.
- [3]王海燕.牛蒡子化学成分研究[J].药学学报,1993,28(12):911.
- [4]AKIHIKO S.Studies on anticancer properties of crude drugs-anticancer propertyof fructus arctii[J].Foreign Medica Sci-Traditional Chininese Medicine Herb,1987,9(2):111-116.
- [5]HSEU Y C,CHANG W C,HSEU Y T,et al.Protection of oxidative damage byaqueous extract fromAntrodia camphoratemycelia in normal human erythrocytes[J].Life Sciences,2002,71:469-482.
- [6]EICH E,PERTZ H.Arctigenin as a lead structure for inhibitors of human im-munodeficiency virus type integrase[J].Journal of Medicinal Chemistry,1996,39(1):86-95.
- [7]李大亮,宋杨,周慧华,等.牛蒡子水煎液及牛蒡苷、牛蒡苷元体外抗菌试验研究[J].黑龙江医药,2004,17(6):433-436.
- [8]阎凌霄,李亚明.牛蒡子提取物对小鼠免疫功能及血糖的作用[J].西北药学杂志,1993,8(2):75-78.
- [9]CHO J Y,KIM A R,YOO E S,et al.Immunomodulatory effect of arctigenin,alignan compound,on tumour necrosis factor-alpha and nitric oxide production,and lymphocyte proliferation[J].The Pharmaceutical Society of Japan,1999,51(11):1 267-1 273.
- [10]王小琳,张玉杰,石任兵.正交实验设计优选牛蒡子的提取工艺[J].北京中医药大学学报,2003,26(4):64-65.
- [11]米靖宇,宋纯清.牛蒡子中木脂素类化合物的抗肿瘤及免疫活性[J].时珍国医国药,2002,13(3):168-169.
- [12]孙铁民,梁伟,林莉,等.牛蒡子对癌瘤作用的实验研究[J].辽宁中医学院学报,2002,4(4):310.
- [13]郑国灿.牛蒡子提取液的抗癌性研究[J].东南大学学报:医学版,2003,22(5):319-322.
- [14]HIROSE M,YAMAGUCHI T,lIN C,et al.Effects of aretiin on PHIP-in-duced mammary,colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MelQx-induced hepatocarcinogenes is in male F344 rats[J].Can-cer Letters,2000,155(1):79-88.
- [15]KATOT HIROSEM,TAKAHASHI S.Effects of the lignan,aretiin,on 17-be-ta ethinyl estradiol promotion of preneoplastic liver cell foci development in rats[J].Anticancer Research,1998,18(2A):1 053-1 057.