陈建新;张瑞华;徐明举;利凯;徐彤;

• 1:河北北方学院动物科技学院

摘要(Abstract)：

[目的]确定分离的H9N2亚型猪流感病毒对小鼠的致病性。[方法]利用此株猪流感病毒对SPF级6～8周龄、雌性BALB/c小鼠进行滴鼻感染,观察小鼠临床症状,感染后第2、6和14天分别剖杀小鼠,摘取各主要脏器后对其进行病理学检查。[结果]感染小鼠出现精神不振、体重下降、引起以弥漫性肺泡损伤为主的临床症状和病理变化。[结论]该研究成功进行了H9N2猪流感病毒对BALB/c小鼠的感染,可以作为感染模型进行H9N2猪流感病毒的发病机制、疫苗评价、药物筛选等研究。

关键词(KeyWords)： 猪流感病毒;H9N2亚型;致病性

Abstract:

Keywords:

基金项目(Foundation): 河北省自然基金课题“H9N2亚型猪流感病毒株分子流行病学及其对小鼠肺损伤机理的研究”(20091001028)

作者(Author): 陈建新;张瑞华;徐明举;利凯;徐彤;

Email:

DOI: 10.13989/j.cnki.0517-6611.2011.21.002

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