田景梅;张扬;张云峰;杨绍兴;邓黎霞;赖思晨;

• 1:云南师范大学生命科学学院
• 2:上海海洋大学海洋科学学院
• 3:教育部生物能源持续开发利用工程中心

摘要(Abstract)：

对黄酮类对调节脂肪平衡、降低心血管疾病发生的机制进行阐述。

关键词(KeyWords)： 类黄酮;动脉硬化症;磷酸二酯酶;脂肪水解;脂肪组织;肝脏

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(30660075、40861019);; 云南科技厅社会发展科技计划基础研究面上项目(2009CD052);; 云南省应用基础研究计划(2011FA016)

作者(Author): 田景梅;张扬;张云峰;杨绍兴;邓黎霞;赖思晨;

Email:

DOI: 10.13989/j.cnki.0517-6611.2012.09.083

参考文献(References)：

• [1]刘成伦,唐德容.黄酮类物质抗氧化性质的研究进展[D].重庆:重庆大学化学化工学院,2006.
• [2]TIMBERLAKE C F,HENRY B S.Plant pigments as natural food colours[J].Endeavour,1986,10:31-36.
• [3]张华峰.类黄酮合成研究现状与展望[D].北京:中国科学院研究生院,2006.
• [4]NESS A R,POWLES J W.Fruit and vegetables,and cardiovascular dis-ease:a review[J].Epidemiol,1997,26(1):1-13.
• [5]HOWARD B V,KRITCHEVSKY D.Phytochemicals and cardiovasculardisease:a statement for healthcare professionals from the American HeartAssociation[J].Circulation,1997,95:2591-2593
• [6]Anonymous.USDA-Iowa State University database on the isoflavone contentof foods,1.3-2002[Z].2002.
• [7]Anonymous.USDA database for the flavonoid content of selected foods[Z].2003.
• [8]CHIBA H,UEHARA M,WU J,et al.Hesperidin,a citrus flavonoid,inhibitsbone loss and decreases serum and hepatic lipids in ovariectomized mice[J].Nutr,2003,133:1892-1897.
• [9]ALI A A,VELASQUEZ M T,HANSEN C T.Modulation of carbohydratemetabolism and peptide hormones by soybean isoflavones and probiotics inobesity and diabetes[J].Nutr Biochem,2005,16:693-699.
• [10]DAVIS J,IQBAL M J,STEINLE J.Soy protein influences the developmentof the metabolic syndrome in male obese ZDFxSHHF rats[J].HormMetab Res,2005,37:316-325.
• [11]KNEKT P,KUMPULAINEN J,JARVINEN R,et al.Flavonoid intake andrisk of chronic diseases[J].Clin Nutr,2002,76:560-568.
• [12]GOLDBERG D I,KHOO J C.Activation of myocardial neutral triglyceridelipase and neutral cholesterol esterase by cAMP-dependent protein kinase[J].Biol Chem,1985,260:5879-5882.
• [13]GLASS C K,WITZTUM J L.Atherosclerosis:the road ahead[J].Cell,2001,104:503-516.
• [14]ZSILA F,BIKADI Z,SIMONYI M.Probing the binding of the flavonoid,quercetin to human serum albumin by circular dichroism,electronic ab-sorption spectroscopy and molecular modelling methods[J].BiochemPharmacol,2003,65:447-456.
• [15]RUGGERI Z M.Platelets in atherosclerosis[J].Nat Med,2002,8:1227-1234.
• [16]NAKASHIMA S,KOIKE T,NOZAWA Y.Genistein,a protein tyrosine ki-nase inhibitor,inhibits thromboxane A2-mediated human platelet respon-ses[J].Mol Pharmacol,1991,39:475-480.
• [17]ROBAK J,KORBUT R,SHRIDI F,et al.On the mechanism of antiag-gregatory effect of myricetin[J].Pol J Pharmacol,1998,40:337-340.
• [18]TEEDE H J,MCGRATH B P,DESILVA L,et al.Isoflavones reduce arte-rial stiffness:a placebo-controlled study in men and postmenopausalwomen[J].Arterioscler Thromb Vasc Biol,2003,23:1066-1071.
• [19]NESTEL P.Isoflavones:their effects on cardiovascular risk and functions[J].Curr Opin Lipidol,2003,14:3-8.
• [20]MACKOWIAK P,NOGOWSKI L,NOWAK K W.Effect of isoflavonegenistein on insulin receptors in perfused liver of ovariectomized rats[J].Recept Sig Transduct Res,1999,19:283-292.
• [21]ZIMMERMANN-BELSING T,FELDT-RASMUSSEN U.Obesity:the newworldwide epidemic threat to general health and our complete lack of ef-fective treatment[J].Endocrinology,2004,145:1501-1502.
• [22]CHEUNG P,YANG G,BODEN G.Milrinone,a selective phosphodiester-ase 3 inhibitor,stimulates lipolysis,endogenous glucose production,andinsulin secretion[J].Metabolism,2003,52:1496-1500.
• [23]DIXON J L,GINSBERG H N.Regulation of hepatic secretion of apoli-poprotein B-containing lipoproteins:information obtained from culturedliver cells[J].J Lipid Res,1993,34:167-179.
• [24]STRINGFIELD T M,MORIMOTO B H.Modulation of cyclic AMP levelsin a clonal neural cell line by inhibitors of tyrosine phosphorylation[J].Biochem Pharmacol,1997,53:1271-1278.
• [25]MULLEN E,BROWN R M,OSBORNE T F,et al.Soy isoflavones affectsterol regulatory element binding proteins(SREBPs)and SREBP-regula-ted genes in HepG2 cells[J].Nutr,2004,134:2942-2947.
• [26]WILCOX L J,BORRADAILE N M,de DREU L E,et al.Secretion of hep-atocyte apoB is inhibited by the flavonoids,naringenin and hesperetin,viareduced activity and expression of ACAT2 and MTP[J].Lipid Res,2001,42:725-734.
• [27]BORRADAILE N M,de DREU L E,BARRETT P H R,et al.HepatocyteapoB-containing lipoprotein secretion is decreased by the grapefruit fla-vonoid,naringenin,via inhibition of MTP-mediated microsomal triglycer-ide accumulation[J].Biochemistry,2003,42:1283-1291.
• [28]CASASCHI A,RUBIO B K,MAIYOH G K,et al.Inhibitory activity of di-acylglycerol acyltransferase(DGAT)and microsomal triglyceride transferprotein(MTP)by the flavonoid,taxifolin,in HepG2 cells:potential role inthe regulation of apolipoprotein B secretion[J].Atherosclerosis,2004,176:247-253.
• [29]PELUSO M R,WINTERS T A,SHANAHAN M F,et al.A cooperative in-teraction between soy protein and its isoflavone-enriched fraction lowershepatic lipids in male obese Zucker rats and reduces blood platelet sensi-tivity in male Sprague-Dawley rats[J].Nutr,2000,130:2333-2342.
• [30]KIM S,SOHN I,LEE Y S,et al.Hepatic gene expression profiles are al-tered by genistein supplementation in mice with diet-induced obesity[J].Nutr,2005,135:33-41.
• [31]BOK S H,LEE S H,PARK Y B,et al.Plasma and hepatic cholesterol andhepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acylCoA:cholesterol transferase are lower in rats fed citrus peel extract or amixture of citrus bioflavonoids[J].Nutr,1999,129:1182-1185.
• [32]KAWAKAMI Y,TSURUGASAKI W,NAKAMURA S,et al.Comparison ofregulative functions between dietary soy isoflavones aglycone and gluco-side on lipid metabolism in rats fed cholesterol[J].Nutr Biochem,2005,16:205-212.
• [33]KEPPENS S.Effect of genistein on both basal and glucagon-induced lev-els of cAMP in rat hepatocytes[J].Biochem Pharmacol,1995,50:1303-1304.
• [34]den BOER M,VOSHOL P J,KUIPERS F,et al.Hepatic steatosis:a medi-ator of the metabolic syndrome:lessons from animal models[J].Arterio-scler Thromb Vasc Biol,2004,24:644-649.
• [35]PATEL R T,SOULAGES J L,HARIHARASUNDARAM B,et al.Activa-tion of the lipid droplet controls the rate of lipolysis of triglycerides in theinsect fat body[J].Biol Chem,2005,280:22624-22631.
• [36]ALAM M,HO S,VANCE D E,et al.Heterologous expression,purification,and characterization of human triacylglycerol hydrolase[J].Protein ExprPurif,2002,24:33-42.
• [37]DOLINSKY V W,GILHAM D,ALAM M,et al.Triacylglycerol hydrolase:role in intracellular lipid metabolism[J].Cell Mol Life Sci,2004,61:1633-1651.
• [38]FERRELL J E Jr,CHANG SING P D,LOEW G,et al.Structure/activitystudies of flavonoids as inhibitors of cyclic AMP phosphodiesterase andrelationship to quantum chemical indices[J].Mol Pharmacol,1979,16:556-568.
• [39]JENKINS C M,MANCUSO D J,YAN W,et al.Identification,cloning,ex-pression,and purification of three novel human calcium-independentphospholipase A2 family members possessing triacylglycerol lipase andacylglycerol transacylase activities[J].Biol Chem,2004,279:48968-48075.
• [40]LAKE A C,SUN Y,LI J L,et al.Expression,regulation,and triglyceridehydrolase activity of adiponutrin family members[J].Lipid Res,2005,46:2477-2487.
• [41]WEI E,LEHNER R,VANCE D E.C/EBP activates the transcription oftriacylglycerol hydrolase in 3T3-L1 adipocytes[J].Biochem,2005,388(3):959-966.
• [42]GIBBONS G F,WIGGINS D.Intracellular triacylglycerol lipase:its role inthe assembly of hepatic very-low-density lipoprotein[J].Adv EnzymeRegul,1995,35:179-198.
• [43]GILHAM D,LEHNER R.The physiological role of triacylglycerol hydro-lase in lipid metabolism[J].Rev Endocr Metab Disord,2004,5:303-309.
• [44]MEZEI O,BANZ W J,STEGER R W,et al.Soy isoflavones exert antidia-betic and hypolipidemic effects through the PPAR pathways in obeseZucker rats and murine RAW 264.7 cells[J].Nutr,2003,133:1238-1243.
• [45]KIM S,SHIN H J,KIM S Y,et al.Genistein enhances expression of genesinvolved in fatty acid catabolism through activation of PPAR[J].Mol CellEndocrinol,2004,220:51-58.
• [46]RICKETTS M L,MOORE D D,BANZ W J,et al.Molecular mechanismsof action of the soy isoflavones includes activation of promiscuous nuclearreceptors:a review[J].Nutr Biochem,2005,16:321-330.
• [47]DOLINSKY V W,GILHAM D,HATCH G H,et al.Regulation of triacylg-lycerol hydrolase expression by dietary fatty acids and peroxisomal prolif-erator-activated receptors[J].Biochim Biophys Acta,2003,1635:20-28.
• [48]WORD M J,LOVELL S C,RICHARDSON J S,et al.Asparagine and glu-tamine:using hydrogen atom contacts in the choice of side-chain amide o-rientation[J].Mol Biol,1999 285:1735-1747.