尚延丽;冯霞;靳野;张晓霞;张柳;马军武;

• 1:中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室/国家口蹄疫参考实验室

摘要(Abstract)：

[目的]预测A型口蹄疫病毒结构蛋白VP1的H-2d限制性T细胞表位。[方法]使用多种在线表位预测软件,包括Syfpeithi、IEDB、Net MHC-3.2、IMTECH和BIMAS预测A型口蹄疫病毒VP1上可能有的H-2d限制性T细胞表位,然后用Prot Param软件分析预测出的候选表位。[结果]综合比较5个表位预测软件的预测结果,遴选出10个候选表位;再结合Prot Param软件分析结果,最后共预测出5个表位:其中H-2Kd限制性表位有第27~35、118~126位,H-2Ld限制性表位有第43~51位,H-2Dd限制性表位有第45~53、146~154位。[结论]预测出5条口蹄疫病毒结构蛋白VP1 H-2d限制性CTL表位,为进一步鉴定口蹄疫病毒CTL表位提供数据和基础。

关键词(KeyWords)： 口蹄疫病毒;结构蛋白VP1;H-2d限制性T细胞表位;生物信息学

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 尚延丽;冯霞;靳野;张晓霞;张柳;马军武;

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参考文献(References)：

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