口蹄疫病毒A/GDMM/CHA/2013株结构蛋白VP1 H-2d限制性CTL表位预测Prediction of H-2d Restricted CTL Epitope of Structural Protein VP1 of FMDV A / GDMM / CHA /2013 Strains
尚延丽;冯霞;靳野;张晓霞;张柳;马军武;
摘要(Abstract):
[目的]预测A型口蹄疫病毒结构蛋白VP1的H-2d限制性T细胞表位。[方法]使用多种在线表位预测软件,包括Syfpeithi、IEDB、Net MHC-3.2、IMTECH和BIMAS预测A型口蹄疫病毒VP1上可能有的H-2d限制性T细胞表位,然后用Prot Param软件分析预测出的候选表位。[结果]综合比较5个表位预测软件的预测结果,遴选出10个候选表位;再结合Prot Param软件分析结果,最后共预测出5个表位:其中H-2Kd限制性表位有第27~35、118~126位,H-2Ld限制性表位有第43~51位,H-2Dd限制性表位有第45~53、146~154位。[结论]预测出5条口蹄疫病毒结构蛋白VP1 H-2d限制性CTL表位,为进一步鉴定口蹄疫病毒CTL表位提供数据和基础。
关键词(KeyWords): 口蹄疫病毒;结构蛋白VP1;H-2d限制性T细胞表位;生物信息学
基金项目(Foundation):
作者(Author): 尚延丽;冯霞;靳野;张晓霞;张柳;马军武;
Email:
DOI: 10.13989/j.cnki.0517-6611.2015.16.053
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