周自福;张建华;郑怡婷;占文婷;黄倞文;钱炳俊;

• 1:上海交通大学农业与生物学院食品科学与工程系

摘要(Abstract)：

高血压已成为全球最常见的心血管疾病,其中肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)发挥着重要的血压调节作用,血管紧张素转化酶(angiotensin-converting enzyme,ACE)催化血管紧张素Ⅰ转化为血管紧张素Ⅱ,并使缓激肽失活,因此,其抑制剂成为抗高血压药物研究的靶点。许多研究表明小肽具有ACE活性抑制作用,存在调控高血压的潜力。海洋生物种类丰富,具有潜在的生物活性肽的开发价值。对来自海洋生物的抗高血压生物活性肽的生产和构效关系(Structure-Activity Relationship,SAR)的研究现状进行综述。

关键词(KeyWords)： 海洋生物;ACE抑制肽;降血压;制备;构效关系

Abstract:

Keywords:

基金项目(Foundation): 国家海洋局公益性行业计划(201205031)

作者(Author): 周自福;张建华;郑怡婷;占文婷;黄倞文;钱炳俊;

Email:

DOI: 10.13989/j.cnki.0517-6611.2015.26.247

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