抗多重耐药金黄色葡萄球菌土壤放线菌筛选Screening of Actinomycetes from Soil to Inhibit the Growth of Multi-resistant Staphylococcus aureus
陈国华;何晓雯;邵伟;乐超银;
摘要(Abstract)：
[目的]从土壤中发现拮抗多重耐药金黄色葡萄球菌的放线菌。[方法]将土壤稀释后在高氏一号培养基上划线分离放线菌,并测试抗菌活性。[结果]获得放线菌一株B0602具有很强的抗菌活性。[结论]放线菌B0602可能开发出高活性的抗生素制品。
关键词(KeyWords)： 土壤放线菌;多重耐药金黄色葡萄球菌;放线菌筛选
基金项目(Foundation): 三峡大学科研启动基金(0620060113);; 湖北省教育厅科学研究计划(Q200713002)
作者(Author): 陈国华;何晓雯;邵伟;乐超银;
Email:
DOI: 10.13989/j.cnki.0517-6611.2008.35.051
参考文献(References)：
- [1]中国药学会抗生素专业委员会.抗生素科学的进展[J].中国药学杂志,1997,32(11):698-700.
- [2]MONAGHANR L,BARRETTJ F.Antibacterial drug discovery-then,nowand the genomicsfuture[J].Biochemical Pharmacology,2006,7:901-909.
- [3]WALSHC,DUFFYG,O′MAHONYR,et al.Antimicrobial resistance in I-rish isolates of verocytotoxigenicEscherichia coli(E.coli)-VTEC[J].Inter-national Journal of Food Microbiology,2006,109:173-178.
- [4]THRELFALLEJ,DAYM,DEPINNAE,etal.Drug-resistantenteric feverin the UK[J].The Lancet,2006,367:1576.
- [5]刘一江,黄乾明,杨洲平,等.仙人掌抗菌肽的筛选、分离纯化及性质研究[J].四川农业大学学报,2007,25(3):271-276.
- [6]CASTILLO U F,STROBEL G A,FORD E J,et al.Mununabicins,wide-spectrumantibiotics produced by Streptomyces NRRL30 562,endophyticonKenndia nigriscans[J].Microbiology,2002,148:2675-2685.
- [7]刘灵芝,胡江春,陈锡时.一株产抗生素链霉菌的研究初报[J].中国生态农业学报,2007,15(3):123-125.
- [8]WANGJ,ZHUJ H,HUANGYL,et al.Screening for the strain highlyproducing antagonistic substance fromBacillus subtilisB47 by UV muta-genesis[J].Agricultural Science&Technology,2008,9(4):68-72.
- [9]陆亚华,时庭文,陈虹,等.耐甲氧西林金黄色葡萄球菌耐药性及耐药基因研究[J].中华检验医学杂志,2005(7):76-77.