基于电子效应的氨基酸分类与二级结构的倾向性分析Tendency Analysis on Amino Acids Categorization and Secondary Structure Based on Electronic Effect
蔡渡江;王联结;
摘要(Abstract)：
依据氨基酸侧链基团的电子效应,将17种氨基酸(Pro、Gly、Cys除外)划分为供电子效应氨基酸、吸电子效应氨基酸、弱电子效应氨基酸3类。并计算了该分类情况下氨基酸二级结构的倾向性因子,为了更好的说明该分类与蛋白质二级结构的关系,经讨论得到一个最终的分类结果。该结果很好地说明了氨基酸对于螺旋和无规则卷曲的倾向性。
关键词(KeyWords)： 氨基酸分类;电子效应;蛋白质二级结构
基金项目(Foundation):
作者(Author): 蔡渡江;王联结;
Email:
DOI: 10.13989/j.cnki.0517-6611.2010.36.155
参考文献(References)：
- [1]WANGJ,WANG W.Acomputational approach to simplifying the protein-folding alphabet[J].Nature Structural Biology,1999,6(11):1033-1038.
- [2]MURPHY LR,WALLQVISTAND A,RONALD M.Simplified amino acidalphabets for protein foldrecognition and implications for folding[J].Pro-tein Engineering,2000,13(3):149-152.
- [3]ANFINSENCB,HABERE,SELAM,etal.The kinetics of formation of n-ative ribonuclease during oxidation of the reduced polypeptide chain[J].Proc Natl Acad Sci USA,1961,47:1309-1314.
- [4]李晓琴,罗辽复.用信息聚类方法研究蛋白质的氨基酸组成和二级结构含量的关系[J].内蒙古大学学报:自然科学版,1997,28(1):41-46.
- [5]CHOUP Y,FASMAN G D.Prediction of protein conformation[J].Bio-chemistry,1974,13(2):211-222.
- [6]CHOUP Y,FASMAN G D.Prediction of the secondary structure of pro-teins fromtheir amino acid sequence[J].Adv Enzymol Relat Areas MonBiol,1978,47:45-148.
- [7]ROSTB,SANDERC,SCHNEIDERR.Redefiningthe goals of protein sec-ondary structure prediction[J].Journal of Molecular Biology,1994,235(1):13-26.
- [8]PADMANABHANR,MARQUSEE S,RIDGEWAY T,et al.Relative helix-forming tendencies of nonpolar amino acids[J].Nature,1990,344:268.
- [9]KIMCA,BERGJ M.Thermodynamic beta-sheet propensities measured u-sing a zinc-finger host peptide[J]Nature,1993,362:267-270.
- [10]MINORDL,KIMPS.Measurementofthe b-sheetformingpropensitiesofamino acids[J].Nature,1994,367,660-663.
- [11]SMITHCK,WITHKAJ M,REGANL.Athermodynamic scale forthe be-ta-sheet forming tendencies of the amino acids[J].Biochemistry,1994,33:5510-5517.
- [12]JIANGB,GUO T,PENG L W.Folding type-specific secondary structurepropensities of amino acids,derived fromα-helical,β-sheet,andα+βproteins of knowstructures[J].Biopolymer,1998,45(11):35-49.
- [13]陶慰孙,李惟,姜涌明.蛋白质分子基础[M].2版.北京:高等教育出版社,1995:195.
- [14]阎隆飞,孙之荣.蛋白质分子结构[M].北京:清华大学出版社,1999:11-13.
- [15]王守源,李晓琴,罗辽复.氨基酸分类与蛋白质二级结构相关性[J].内蒙古大学学报:自然科学版,2002,33(4):423-427.