不同取代度乙酰化儿茶素的合成及体外抗氧化活性的研究Synthesis of Acetylated Catechins of Different Substituting Degrees and Their Antioxidant Capacity in vitro
白艳;江和源;江用文;张建勇;王伟伟;龙丹;
摘要(Abstract):
[目的]研究乙酰化儿茶素的相关性质,,以期改善儿茶素的应用特性。[方法]以乙酸酐为酰化剂对表没食子儿茶素没食子酸酯(EGCG)、茶多酚(TP)进行O-酰化修饰,分别合成了2种取代度的乙酰化儿茶素,考察了乙酰化程度对儿茶素溶解性、抗氧化性和紫外吸收能力的影响。[结果]随着取代度的增加,乙酰化儿茶素脂溶性增加,总抗氧化能力和清除超氧阴离子能力降低,清除羟自由基能力增加,紫外吸收带蓝移,吸收强度降低。[结论]研究筛选出高乙酰化儿茶素活性取代产物,从而为定向合成高活性的乙酰化儿茶素提供参考。
关键词(KeyWords): 儿茶素;乙酰化;取代度;溶解性;抗氧化活性;紫外吸收
基金项目(Foundation): 浙江省重大农业科技专项(2010C12023-2);; 浙江省自然科学基金(Y3100036)
作者(Author): 白艳;江和源;江用文;张建勇;王伟伟;龙丹;
Email:
DOI: 10.13989/j.cnki.0517-6611.2012.31.022
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