孙颖;金天明;

• 1:天津农学院动物科学系

摘要(Abstract)：

介绍了菌影制备、裂解效果测定与装载的方法和菌影的作用,阐述了菌影及其导向系统的应用前景。

关键词(KeyWords)： 菌影;递送载体;疫苗

Abstract:

Keywords:

基金项目(Foundation): 天津市高等学校科技发展基金计划项目(20060720);; 天津农学院科学研究发展基金计划重点项目(2006001)

作者(Author): 孙颖;金天明;

Email:

DOI: 10.13989/j.cnki.0517-6611.2009.21.049

参考文献(References)：

• [1]ULRIKE BEATE MAYR,PETRAWALCHER,CHAKAMEHAZIMPOUR,et al.Bacterial ghosts as antigen delivery vehicles[J].Advanced DrugDe-livery Reviews,2005,57(9):1381-1391.
• [2]HERBERTHOFFELNER,RAINER HAAS.Recombinant bacterial ghosts:versatile targeting vehicles and promising vaccine candidates[J].Interna-tional Journal of Medical Microbiology,2004,294(5):303-311.
• [3]KLAUS PANTHEL,WOLFGANGJECHLINGER,ALEXANDERMATIS,etal.Generation of helicobacterpylori ghosts byphiXprotein E-mediated In-activation and theirevaluation as vaccine candidates[J].Infection and Im-munity,2003,71(1):109-116.
• [4]ULRIKE BEATE MAYR,CHRISTOPH HALLER,WOLFGANG HAID-INGER,et al.Bacterial ghosts as an oral vaccine:a single dose ofEsche-richia coliO157:H7 bacterial ghosts protects mice against lethal challenge[J].Infection and Immunity,2005,73(8):4810-4817.
• [5]MARCHARTJ,DROPMANNG,LECHLEITNER S,et al.Pasteurella mul-tocida-and Pasteurella hameolytica-ghosts:newvaccine candidates[J].vac-cine,2003,21:3988-3997.
• [6]ASTRID KATINGER,WERNER LUBITZ,SZOSTAK MICHAEL P,et al.Pigs aerogenously immunized with geneticallyinactivated(ghosts)or irra-diated Actinobacillus pleuropneumoniae are protected againsta homologousaerosol challenge despite differing in pulmonary cellular and antibody re-sponses[J].Journal of Biotechnology,1999,73:251-260.
• [7]VERONIKA HUTER,ANDREAS HENSEL,EDITH BRAND,et al.Im-proved protection against lung colonization byActinobacillus pleuropneu-moniaeghosts:characterization of a genetically inactivated vaccine[J].Journal of Biotechnology,2000,83:161-172.
• [8]常月红,刘思国,王春来,等.猪传染性胸膜肺炎放线杆菌“菌影”的制备[J].中国预防兽医学报,2008,30(9):674-677.
• [9]王丽哲.裂解基因E和SN基因原核表达载体构建及大肠杆菌O138菌影的研制[D].长春:吉林大学,2007.
• [10]HAIDINGERW,SZOSTAKMP,JECHLINGERW,etal.Online monito-ringofEscherichia colighost production[J].Applied and EnvironmentalMicrobiology,2003,69(1):468-474.
• [11]THOMAS EBENSEN,SUSANNE PAUKNER,CLAUDIA LINK,et al.Bacterial ghostsare anefficientdeliverysystemforDNAvaccines[J].TheJournal of Immunology,2004,172:6858-6865.
• [12]HASLBERGER AG,KOHL G,FELNEROVAD,et al.Activation,stimu-lation and uptake of bacterial ghosts in antigen presentingcells[J].Jour-nal of Biotechnology,2000,83:57-66.
• [13]RIEDMANNE M,KYD J M,SMITHAM,et al.Construction of recombi-nant S-layer proteins(rSbsA)and theirexpression in bacterial ghosts-adelivery system for the nontypeableHaemophilus influenzaeantigenOmp26[J].FEMS Immunology and Medical Microbiology,2003,37:185-192.
• [14]PETRAWALCHER,XIANLANCUI,ARROWJ A,et al.Bacterial ghostsas a delivery system for zona pellucida-2 fertility control vaccines forbrushtail possums[J].Vaccine,2008,26(52):6832-6838.
• [15]SERYUNKWON,YOONKWONNAM,SUNGKOOKIM,et al.Gener-ation of Edwardsiella tarda ghosts by bacteriophage PhiX174 lysis gene E[J].Aquaculture,2005,250(1/2):16-21.