基因疫苗的免疫学分子机制The Molecule Immune Mechanism of Gene Vaccine
齐麟;向志明;张彤;
摘要(Abstract):
文中对病原体诱导宿主的免疫学过程以及基因疫苗作用的免疫学分子机制进行了综述,并对其未来发展进行了展望。
关键词(KeyWords): 基因疫苗;抗原提呈;主要组织相溶性复合物
基金项目(Foundation): 有害生物控制与资源利用国家重点实验室开放课题(SKLBC2010K06);; 公安部科技创新项目(2010YYCXTDGZ125);; 河南省教育厅基础研究项目(200510475016)
作者(Author): 齐麟;向志明;张彤;
Email:
DOI: 10.13989/j.cnki.0517-6611.2012.27.052
参考文献(References):
- [1]WOLFF J A,MALONE R W,WILLIAMS P,et al.Direct gene transfer intomouse muscle in vivo[J].Science,1990,247:1465-1468.
- [2]TANG D C,DEVIT M,JOHNSTON S A.Genetic immunization is a simplemethod for eliciting an immune response[J].Nature,1992,356:152-154.
- [3]BHARDWAJ N,YOUNG J W,NISANIAN A J,et al.Small amounts ondendritic cells,are sufficient to initiate T cell responses[J].J Exp Med,1993,178:633-642.
- [4]FYNAN E F,ROBINSON H L,WEBSTER R G.Use of DNA encoding in-fluenza hemagglutinin as an avian influenza vaccine[J].DNA Cell Biol,1993,12(9):785-789.
- [5]DAVIS H L,MILLAN C L,WATKINS S C.Immune-mediated destructionof transfected muscle fibers after direct gene transfer with antigen-ex-pressing plasmid DNA[J].Gene Ther,1997,4(3):181-188.
- [6]ULMER J B,LIU M A,MONTGOMERY D L,et al.Expression and immu-nogenicity of of superantigen,when presented Mycobacterium tuberculosisantigen 85 by DNA vaccination[J].Vaccine,1997,15(8):792-794.
- [7]ULMER J B,DECK R R,DEWITT C M,et al.Expression of a viral proteinby muscle cells in vivo induces protective cell-mediated immunity[J].Vaccine,1997,15(8):839-841.
- [8]ULMER J B,DECK R R,DEWITT C M,et al.Induction of immunity byDNA vaccination:application to influenza and tuberculosis[J].BehringInst Mitt,1997,98:79-86.
- [9]MANICKAN E,ROUSE B T.Roles of different T-cell subsets in controlof herpes simplex virus infection determined by using T-cell-deficientmouse-models[J].J Virol,1995,69(12):8178-8179.
- [10]MANICKAN E,FRANCOTTE M,KUKLIN N,et al.Vaccination with re-combinant vaccinia viruses expressing ICP27 induces protective immunityagainst herpes simplex virus through CD4+Th1+T cells[J].J Virol,1995,69(8):4711-4716.
- [11]FLO J,TISMINETZKY S,BARALLE F.Oral transgene vaccination media-ted by attenuated Salmonellae is an effective method to prevent Herpessimplex virus-2 induced disease in mice[J].Vaccine,2001,19(13/14):1772-1782.
- [12]DARJI A,ZUR LAGE S,GARBE A I,et al.Oral delivery of DNA vac-cines using attenuated Salmonella typhimurium as carrier[J].FEMS Im-munol Med Microbiol,2000,27(4):341-349.
- [13]DIETRICH G,SPRENG S,GENTSCHEV I,et al.Bacterial systems for thedelivery of eukaryotic antigen expression vectors[J].Antisense NucleicAcid Drug Dev,2000,10(5):391-399.
- [14]PERTMER T M,EISENBRAUN M D,MCCABE D,et al.Gene gun-based nucleic acid immunization:elicitation of humoral and cytotoxic Tlymphocyte responses following epidermal delivery of nanogram quantitiesof DNA[J].Vaccine,1995,13(15):1427-1430.
- [15]WRIGHT P,BRAUN R,BABIUK L,et al.Adenovirus-mediated TNF-alpha gene transfer induces significant tumor regression in mice[J].Cancer Biother Radiopharm,1999,14(1):49-57.
- [16]BOWNE W B,WOLCHOK J D,HAWKINS W G,et al.Injection of DNAencoding granulocyte-macrophage colony-stimulating factor recruitsdendritic cells for immune adjuvant effects[J].Cytokines Cell Mol Ther,1999,5(4):217-225.
- [17]MAECKER H T,HANSEN G,WALTER D M,et al.Vaccination with al-lergen-IL-18 fusion DNA protects against,and reverses established,airway hyperreactivity in a murine asthma model[J].J Immunol,2001,66(2):959-965.
- [18]DAS M P,NICHOLSON L B,GREER J M,et al.Autopathogenic T helpercell type 1(Th1)and protective Th2 clones differ in their recognition ofthe autoantigenic peptide of myelin proteolipid protein[J].J Exp Med,1997,186(6):867-876.
- [19]FYNAN E F,ROBINSON H L,WEBSTER R G.Use of DNA encoding in-fluenza hemagglutinin as an avian influenza vaccine[J].DNA Cell Biol,1993,12(9):785-789.
- [20]QIU J T,SONG R,DETTENHOFER M,et al.Evaluation of novel humanimmunodeficiency virus type 1 Gag DNA vaccines for protein expressionin mammalian cells and induction of immune responses[J].J Virol,1999,73:9145-9152.
- [21]QIU P,ZIEGELHOFFER P,SUN J,et al.Gene gun delivery of mRNA insitu results in efficient transgene expression and genetic immunization[J].Gene Ther,1996,3(3):262-268.