鸡大肠杆菌重组1型菌毛疫苗的免疫原性Immunogenicity of Vaccine against Recombinant Type 1 Pilus of Avian Escherichia coli in Chickens
甘黎明;蒋加进;陈钟鸣;张志成;戴鼎震;
摘要(Abstract):
[目的]制备鸡大肠杆菌重组1型菌毛疫苗,并探索其免疫原性。[方法]从含1型菌毛的基因重组菌株CZYR10与野生型鸡大肠杆菌分离株YR(018)中提取1型菌毛,制备菌毛油乳剂疫苗。通过对鸡群的攻毒试验,探讨该疫苗的免疫原性。[结果]重组1型菌毛蛋白具有免疫保护作用。重组1型菌毛疫苗的保护力比分离的鸡大肠杆菌1型菌毛疫苗保护率低,但差异不显著(P>0.05)。[结论]该研究可为鸡大肠杆菌病的免疫防治提供依据。
关键词(KeyWords): 鸡大肠杆菌;重组1型菌毛疫苗;免疫原性
基金项目(Foundation): 江苏省自然科学基金资助(BK2008059)
作者(Author): 甘黎明;蒋加进;陈钟鸣;张志成;戴鼎震;
Email:
DOI: 10.13989/j.cnki.0517-6611.2011.36.014
参考文献(References):
- [1]NAVEH M W,ZUSMAN T,SKUTELSKY E,et al.Adherence pili in avianstrains of Escherichia coli:effect on pathogenicity[J].Avian Dis,1984,28:651-661.
- [2]LA RAGIONE R M,SAYERS A R,WOODWARD M J.The role of fimbriaeand flagella in the coloniation,invasion andpersistence of Escherrichia coliO78:K80 in the day-old-chick model[J].Epidemiology and Infection,2000,124:351-363.
- [3]戴鼎震,汤厚宽,李复中,等,鸡大肠杆菌多价1型菌毛亚单位疫苗在鸡体内的免疫原性研究[J].中国预防兽医学报,2000,22(5):338-340.
- [4]GYIMAH J E,PANIGRAPHY B,WILLIAMMS J D.Immunogenicity of anEscherichia coli(serotype O1)[J].Avian Disease,1985,29:1078-1083.
- [5]GYIMAH J E,PANIGRAPHY B,WILLIAMMS J D.Immunogenicity of anEscherichia coli mulimultivalent pilus vaccine in chickens[J].Avian Dis-ease,1986,30:687-689.
- [6]王国相.大肠杆菌Ⅰ型菌毛操纵子fim基因的克隆表达及部分亚单位功能初探[D].扬州:扬州大学,2008.
- [7]GYIMAH J E,PANIGRAHY B.Immunogenicity of an oil-emulsified Esche-richia coli(O1)pili vaccine in chickens[J].Avian Disease,1985,29:1078-1083.
- [8]戴鼎震,郑明球,恽时锋,等.鸡大肠杆菌I型菌毛亚单位苗交叉保护的初步研究[J].畜牧与兽医,1999,31(5):1-2.