治疗性疫苗国内外研发现状与发展趋势
曹王丽;王如伟;方玲;胡江宁;金朱明;
摘要(Abstract):
综述治疗性疫苗国外上市、研发情况及其国内的发展现状,提出治疗性疫苗可能的研发趋势。综合治疗性疫苗研发现状分析其应用前景。指出国外对于治疗性疫苗的开发走在前列,国内企业应该充分运用国家优惠政策,依据我国疾病发生的类型,寻求突破,创新研制新药,开发新产品,增强市场竞争力。
关键词(KeyWords): 治疗性疫苗;上市;肿瘤;传染性疾病;研发现状;发展趋势
基金项目(Foundation):
作者(Author): 曹王丽;王如伟;方玲;胡江宁;金朱明;
Email:
DOI: 10.13989/j.cnki.0517-6611.2013.36.137
参考文献(References):
- [1]KIRKWOOD J M,BUTTERFIELD L H,TARHINI A A,et al.Immunotherapy of Cancer in 2012[J].CA:Cancer Journal for Clinicians,2012,62(5):309-335.
- [2]KEIJZER C,VAN DER ZEE R,VAN EDEN W,et al.Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases[J].Front Immunol,2013,20(4):245.
- [3]MADAN R A,SCHWAAB T,GULLEY J L.Strategies for optimizing the clinical impact of immunotherapeutic agents such as sipuleucel-T in prostate cancer[J].J Natl Compr Canc Netw,2012,10(12):1505-1512.
- [4]AKBAR S M,AL-MAHTAB M,UDDIN M H,et al.HBsAg,HBcAg,and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection[J].Hepatobiliary Pancreat Dis Int,2013,12(4):363-369.
- [5]Rethinking therapeutic cancer vaccines[J].Nat Rev Drug Discov,2009,8:685-686.
- [6]GONZALEZ G,CROMBET T,LAGE A.Chronic vaccination with a therapeutic EGF-based cancer vaccine:a review of patients receiving long lasting treatment[J].Curr Cancer Drug Targets,2011,11(1):103-110.
- [7]SCHLOM J,GULLEY J L,ARLEN P M.Paradigm shifts in cancer vaccine therapy[J].Exp Biol Med(Maywood),2008,233:522-534.
- [8]VAN DOORSLAER K,REIMERS L L,STUDENTSOR Y Y,et al.Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia[J].Gynecol Oncol,2010,116(2):208-212.
- [9]PALUCKA K,BANCHEREAU J.Dendritic-cell-based therapeutic cancer vaccines[J].Immunity,2013,39(1):38-48.
- [10]TOPALIAN S L,WEINER G J,PARDOLL D M.Cancer immunotherapy comes of age[J].Clin Oncol,2011,29(36):4828-4836.
- [11]ROTHSCHILD S,ZIPPELIUS A.Cancer immunotherapy-novel perspectives[J].Ther Umsch,2012,69(10):559-563.
- [12]KIESSLING A,FUSSEL S,WEHNER R,et al.Advances in specific immunotherapy for prostate cancer[J].Eur Urol,2008,53(4):694-708.
- [13]HAMMERSTROM A E,CAULEY D H,ATKINSON B J,et al.Cancer immunotherapy:sipuleucel-T and beyond[J].Pharmacotherapy,2011,31(8):813-828.
- [14]SOSMAN J A,SONDAK V K.Melacine:an allogeneic melanoma tumor cell lysate vaccine[J].Expert Rev Vaccines,2003,2(3):353-368.
- [15]DI PIETRO A,TOSTI G,FERRUCCI P F,et al.Oncophage:step to the future for vaccine therapy in melanoma[J].Expert Opin Biol Ther,2008,8(12):1973-1984.
- [16]RODRGUEZ P C,RODRGUEZ G,GONZLEZ G,et al.Clinical development and perspectives of CIMAvax EGF,Cuban vaccine for non-smallcell lung cancer therapy[J].MEDICC Rev,2010,12(1):17-23.
- [17]GUO C,MANJILI M H,SUBJECK J R,et al.Therapeutic cancer vaccines:past,present,and future[J].Adv Cancer Res,2013,119:421-475.
- [18]WANG S,CHEN Y W.Current development situation of biological medicine industrial parks and counter measures in China[J].Chinese Pharmaceutical Affairs,2012,26(10):1048-1051.
- [19]LIU S Q,GAO Y Q.The Research development of HBeAg-negative chronic hepatitis B[J].Chinese Hepatology,2012,17(6):429-432.
- [20]FANG X,LIANG Z L.The research development of viral hepatitis vaccine in China[J].Chin Pharm J,2012,47(18):1425-1429.
- [21]WEN Y M.The research development of Therapeutic vaccines[J].Chinese Journal of Microbiology and Immunology,1996,16(3):155-158.
- [22]WEN Y M,HE L F,QU T.The research development of therapeutic recombinant hepatitis B vaccine(YIC)[J].Engineering Science,1999,1(1):38-42,57.
- [23]CHEN G M.Development and application of therapeutic HBV DNA vaccine[J].Med J Chin PLA,2003,28(8):489-492.
- [24]WANG Y B.Preparation of Mouse-anti-human ATP Synthase F1 Domain Monoclonal Antibody and Its Effects on Proliferation and Invasion of Cells of Primary Liver Carcinoma[D].Shanghai:The Second Military Medicine University,2009.
- [25]CAO X T.Differentiation,antigen presentation and functional regulation of dendritic cells[J].Aead J Sec Mil Med Uni,2004,25(3):547-549.
- [26]CAO Z L,ZHU S L.The epidemiology and current research of vaccine of HIV/AIDS in China[J].Acta Academiae Medicinae CPAF,2011,20(10):842-844.
- [27]GENG Y H,YANG L,BI D Z.The progress of Liposomes as immunological adjuvants[J].Chin Pharm J,2007,42(9):649-651.
- [28]WU W T,WANG Y T,WU W J.The sustained and rapid development of bio-pharmaceutical industry[J].Chin Pharm J,2010,45(24):1881-1888.